Reuptake is neurotransmitter reabsorption by transporters in axon terminals. Neurotransmitters are too large and hydrophilic for membrane diffusion. First primary reuptake protein sequence published in 1990
Worldwide, 251-310 million people suffer from depression. About 3.4% of global population has depression. Depression affects 1 in 15 adults annually
SSRIs block serotonin reuptake, making more serotonin available for brain cell communication. FDA-approved SSRIs include citalopram, escitalopram, fluoxetine, paroxetine, and sertraline. Can be used for both depression and anxiety disorders
Serotonin is a neurotransmitter that stimulates brain's reward center. Low serotonin levels increase risk of depression and other mental health issues. Serotonin levels can be too high, leading to serotonin syndrome
SSRIs are the most commonly prescribed antidepressants for depression and anxiety. About 13% of U.S. adults take antidepressants, with higher rates among women. They work by enhancing brain nerve cells' function regulating emotion
Sadness can be a sign of depression but doesn't always indicate it. Depression and sadness can occur suddenly or gradually. Feeling sad alone doesn't necessarily mean depression