Serotonin is a 5-hydroxytryptamine (5-HT) compound with molecular formula C10H12N2O. Solubility is 25.5 mg/mL according to Human Metabolome Project. LogP value is 0.21
Carcinoid tumors are slow-growing neuroendocrine tumors originating in gut cells. Most commonly found in small intestine, particularly ileum and appendix. Can rarely arise from ovary or thymus. Median age at diagnosis is 63 years
EC cells are neuroendocrine cells located in digestive tract crypts. Discovered by Nikolai Kulchitsky, they regulate intestinal motility and secretion. Secrete serotonin and other peptides to modulate enteric nervous system. Can communicate directly with vagal neurons through neuropod cells
Neurohormones are hormones produced by neuroendocrine cells into blood. Can function as neurotransmitters or local messengers. Synthesis and release are co-regulated by hormonal, local and synaptic signals
SSRIs are the most commonly prescribed antidepressants for depression and anxiety. Depression affects 6.7% of US population annually. Medications work by increasing serotonin levels in the body
Serotonin is a neurotransmitter that stimulates brain's reward center. Low serotonin levels increase risk of depression and other mental health issues. Serotonin levels can be too high, leading to serotonin syndrome