Millions worldwide experience nighttime leg discomfort. Paresthesia causes tingling or numbness due to nerve compression. Poor circulation and certain sleep positions can contribute
Anemia occurs in 67-83% of patients. Hyperglycemia affects 61% of patients. Neuropathy affects 56% of patients. Neutropenia affects 52% of patients. Fatigue/asthenia affects 44-50% of patients
1357 diabetic patients (56.5% women, 90.4% type 2) were included. DN4 questionnaire and physical examination were used for pain assessment. DN4 score ≥4 was considered neuropathic pain
Sural nerve (L4-S1) supplies posterolateral leg to lateral ankle. Forms from combination of medial sural cutaneous nerve and sural communicating branch. Eight documented variations of sural nerve complex exist. Travels midline posterior to posterolateral around lateral malleolus. Terminates as lateral dorsal cutaneous nerve
Nerve conduction velocity measures the speed of electrochemical impulse propagation. Normal conduction velocities range from 50-60 m/s for most nerves. Myelinated neurons can conduct up to 120 m/s
Neuropathy refers to nerve dysfunction affecting peripheral nervous system. Mononeuropathy affects single nerve, multiple mononeuropathy affects multiple. Polyneuropathy involves many peripheral nerves, common in diabetes. Autonomic neuropathy affects internal organs like heart and blood vessels