EGFR is first discovered RTK receptor activated by extracellular ligands. Receptor contains extracellular ligand-binding, transmembrane, and tyrosine kinase domains. Ligand binding triggers receptor dimerization and kinase domain activation
Exosomes are extracellular vesicles containing proteins, lipids, and nucleic acids. They are produced by all cells and mediate intercellular communication. Exosomes are not immunogenic and can be isolated using various methods
Founded in 1964, headquartered in Tokyo, Osaka and Naruto, Japan. IPO on Tokyo Stock Exchange in 2010 at $2.4 billion. Became Japan's second-largest drug maker by sales in 2010
Multiomics combines multiple omics technologies to study life in concerted way. ASCO defines panomics as combining cell and body function data with patient information. More than 99 software and databases available for multiomic data analysis
K-562 cells are isolated from 53-year-old chronic myelogenous leukemia patient's bone marrow. Widely used in immune system disorder and immunology research. Highly undifferentiated granulocytic series cells. Most closely resembles B population with low Philadelphia chromosome frequency
PA is the most common saturated fatty acid in human body, accounting for 20-30% of total fatty acids. PA is found in palm oil (44%), meat, dairy (50-60%), cocoa butter (26%), and breast milk (20-30%). PA tissue content is tightly controlled, with intake not significantly affecting tissue concentration