Tricyclic antidepressants (TCAs) are a class of medications used to treat depression and other conditions such as anxiety disorders, chronic pain, and migraine 13.

How they work: TCAs increase the levels of serotonin and norepinephrine in the brain, which are neurotransmitters that affect mood 13. They do this by blocking the reuptake of these neurotransmitters, allowing them to stay in the synaptic cleft longer and have a greater impact 35.

Examples of TCAs: Amitriptyline, desipramine, doxepin, imipramine, nortriptyline, protriptyline 12.

Possible side effects: Drowsiness, blurred vision, constipation, dry mouth, weight gain, increased sweating, sexual problems, and others 12.

Precautions: TCAs can interact with other medications and supplements, so it is important to inform the doctor about all taken drugs 12. They should be used with caution in people with certain health conditions, such as glaucoma, enlarged prostate, heart problems, diabetes, and a history of seizures 12.

Overdose: TCAs can be dangerous if taken in excess, so it is necessary to follow the doctor's recommendations and not stop taking the medication suddenly 12.