Neuropathic pain affects 7-10% of the general population. Caused by lesions or diseases of somatosensory system. Multiple causes exist, including diabetes and cancer treatment
Sensory neurons convert stimuli into action potentials via receptors. Cell bodies located in dorsal root ganglia of spinal cord. Information travels through afferent nerve fibers to brain via spinal cord
Carbamazepine treats epilepsy and neuropathic pain. Used as second-line treatment for bipolar disorder. Approved for trigeminal neuralgia treatment. Works as well as phenytoin and valproate for focal seizures
Pain can be acute (sudden) or chronic (long-term). About 70% of chronic pain patients experience breakthrough pain
Neuropathic pain is intense chronic pain caused by damaged nerves. Pain can be described as sharp, burning, tingling, or stabbing. Symptoms typically worsen at night and during rest periods. Can significantly impact quality of life and lead to psychological issues
Allodynia is nerve pain triggered by non-painful stimuli like touch or temperature. Three types exist: tactile, mechanical, and thermal. Pain can vary from sharp to burning or stinging