Biguanide is a colorless solid with formula HN(C(NH)NH2)2. First synthesized by Bernhard Rathke in 1879. Forms highly basic solutions that hydrolyze to ammonia and urea
Galega officinalis is a herbaceous plant native to northern Africa, western Asia and Europe. Widely cultivated as forage, ornamental, bee plant and green manure. Blooms in summer on grasslands, wetlands and riverbanks
Metformin can cause fatal lactic acidosis, especially in patients with renal impairment. Risk factors include age 65+, liver impairment, and excessive alcohol intake. Patients should discontinue metformin before iodinated contrast imaging. Regular monitoring of renal function is necessary
Metformin may cause life-threatening lactic acidosis in kidney disease patients. Alcohol consumption increases risk of lactic acidosis and blood sugar drop. Tell doctor about kidney disease, heart attack, stroke, or liver disease
Lactic acidosis can cause death, hypothermia, and bradyarrhythmias. Risk increases with renal/hepatic impairment and age over 65. Symptoms include malaise, myalgia, respiratory distress, and somnolence
Synjardy contains empagliflozin and metformin for type 2 diabetes treatment. Available as tablets, requires prescription and twice daily with meals. Approved by EMA on 27 May 2015 for adults and children