SBF is a solution with blood plasma-like ion concentration at mild pH and temperature. First introduced by Kokubo et al. for bioactive glass ceramic evaluation. Cell culture media alternatives proposed for assessing material bioactivity
CLL causes excessive production of lymphocytes in bone marrow. Early stages typically show no symptoms. Later symptoms include swollen lymph nodes, fatigue, fever, and weight loss. Disease typically worsens gradually over years
Genome editing modifies DNA in living organisms at specific locations. Three main classes of engineered nucleases: ZFNs, TALENs, and CRISPR/Cas9. Technology pioneered in 1990s before current nuclease-based platforms
CRISPRs were first identified in E. coli in 1987 by Ishino. Mojica and Jansen coined the term CRISPRs in 1993. CRISPR-Cas systems evolved from bacterial immune response to gene editing
PAMAM dendrimers are nanoscopic, spherical polymers with controlled interior/exterior functionalities. Two main families available: Starburst from Dendritech and ASTRAMOL from DSM. Generation 4 PAMAM dendrimer available from Aldrich Co
Chitosan is a natural polysaccharide derived from chitin through N-deacetylation. It is biocompatible, biodegradable and non-toxic with no acidic degradation products. Degree of deacetylation (DDA) affects solubility in dilute acetic acid