TRH is a 242-amino acid hormone produced by hypothalamic neurons. Contains sequence -Gln-His-Pro-Gly- with flanking Lys-Arg or Arg-Arg sequences. Synthesis requires multiple enzyme steps to produce mature form. First determined by Guillemin and Schally in 1969
Hypericum is a genus of flowering plants with over 490 species worldwide. Genus includes 36 sections, with worldwide taxonomic monograph by Norman Robson. Plants occur as trees, shrubs, annuals, and perennials
Bipolar disorder involves severe mood swings with at least one manic episode. Affects over 1% of US adults, up to 4 million people. Fifth leading cause of disability worldwide. Suicide risk 60 times higher than general population
Wellbutrin XL contains 150mg bupropion hydrochloride extended-release tablet. Should be swallowed whole, taken in morning with or without food. Gradual dose increase recommended to minimize seizure risk
Folate is a B vitamin needed for red blood cell production. Folic acid is the man-made form added to processed foods. L-methylfolate is a medical food for folate deficiency
MAO inhibitors block monoamine oxidase enzyme, increasing brain neurotransmitter levels. They also affect dopamine levels, unlike tricyclic antidepressants. Tyramine levels rise when monoamine oxidase is blocked