LA is an autoantibody that interferes with blood clotting. About 2-4% of population has LA, which cannot be measured directly. LA prolongs clotting time in laboratory tests
TEG measures global viscoelastic properties of whole blood clot formation. Test takes around 30 minutes and requires calibration 2-3 times daily. Uses mechanical-electrical transducer with pin suspended in heated cup
ADP consists of sugar backbone, adenine, and two phosphate groups. Can be converted to ATP and AMP through phosphorylation. Breaking one ATP phosphate bond generates 30.5 kJ per mole
FFP is a blood product made from whole blood's liquid portion. Contains water, proteins, carbohydrates, fats, and vitamins. Frozen plasma lasts about a year. First used in medical practice during WWII
Factor X is a serine endopeptidase encoded by F10 gene. Synthesized in liver and requires vitamin K. Half-life is 40-45 hours. Active site divided into four subpockets
Thrombocytopenia is a condition with low platelet count in blood. Platelets help blood clot by forming plugs in vessel injuries. Condition affects both children and adults