Frontal bossing causes enlarged skull bones with pronounced forehead. May include heavy brow ridge and depressed nasal bridge. Can be normal inherited feature or medical condition
PCOS affects 8-13% of reproductive-aged women worldwide. Up to 70% of affected women remain undiagnosed. Leading cause of infertility and anovulation. Runs in families with ethnic variations in manifestations
Cushing syndrome occurs when body produces excessive cortisol. Can result from excessive cortisol production or glucocorticoid medication. Treatment aims to lower cortisol levels and improve symptoms
PCOS affects around 10% of reproductive-aged women worldwide. Guideline developed by international experts and patient groups. Aims to improve care quality and health outcomes for PCOS patients
Puberty occurring unusually early, usually before age 8 in girls or 9 in boys. Two main types: true (central) and pseudoprecocious (peripheral). Can be caused by tumors, brain injuries, or genetic conditions
Testicular atrophy causes testicle size reduction and reduced function. Symptoms include reduced testosterone levels and sexual characteristics. Prepubescent patients show underdeveloped secondary sex characteristics. Postpubescent patients experience lower sex drive and increased breast tissue