Posterior fossa is a dural recess connecting middle and posterior cranial fossa. Upper three cervical spinal nerves supply dura mater in posterior fossa. Trigeminal nerve contributes to dural innervation
Rare inherited disorder causing cystic dilatation of liver bile ducts. Affects about one in 1,000,000 people. Two types exist: focal and diffuse with portal hypertension
Males have two extra chromosomes (1 X and 1 Y) instead of 46. Affects approximately 1 in 18,000-40,000 male births. First described in 1960 by Muldal and Ockey in Manchester
HMG-CoA reductase catalyzes cholesterol biosynthesis from HMG-CoA. Enzyme is anchored in endoplasmic reticulum membrane. Contains eight transmembrane domains, including sterol-sensing and catalytic domains. Gene located on chromosome 5q13.3-14
Most common enzyme deficiency anemia worldwide affecting 400 million people. X-linked recessive disorder causing premature red blood cell breakdown. Most affected individuals are asymptomatic
Frontal bossing causes enlarged skull bones with pronounced forehead. May include heavy brow ridge and depressed nasal bridge. Can be normal inherited feature or medical condition