Textbook emphasizes fundamental genetics concepts and modern genetic analysis techniques. 12th edition includes updated coverage of CRISPR-Cas and posttranscriptional regulation. Text emphasizes ethical considerations in genetics and society. Accompanied by Mastering Genetics platform with interactive learning tools
Molecular genetics studies DNA structure and expression variations among organisms. Field integrates Mendelian inheritance, cellular biology, and biotechnology. DNA is double-stranded molecule with four base pairs: A, T, G, C
DNA strands run parallel but in opposite directions. Nucleic acids have 5' and 3' ends. DNA replication occurs in leading and lagging strands. Hydrogen bonding between base pairs is essential
Hydrogen bond is an electrostatic attraction between hydrogen and electronegative atoms. Most common donors are nitrogen, oxygen, and fluorine. Strength ranges from weak (1-2 kcal/mol) to strong (161.5 kcal/mol in HF-2). Can occur between molecules (intermolecular) or within molecules (intramolecular)
Chromatin is a complex of DNA and proteins found in eukaryotic cells. DNA wraps around histone proteins to form nucleosomes. Nucleosomes can form 11 nm beads-on-a-string structure. 30 nm fiber forms during mitosis, containing mostly inactive genes
DNA is a double-stranded nucleic acid containing genetic information. Nucleotides consist of nitrogenous bases, pentose sugar, and phosphate backbone. DNA strands twist into helical structure with complementary base pairing. Four nitrogenous bases: adenine, thymine, guanine, and cytosine