First identified in 1978 by David Hogness and Michael Goldberg. Found in core promoter regions of archaea and eukaryotes. Contains consensus sequence 5'-TATA(A/T)A(A/T)-3'. Bacterial homolog is Pribnow box with shorter consensus sequence
Gene expression converts genetic information into functional products like proteins or RNA. All life forms use gene expression to generate macromolecular machinery. Genotype determines phenotype through protein synthesis
Cells contain same DNA but express only subset of genes. Gene expression controls when, how much, and when proteins are made. Regulation conserves energy and space by turning genes on only when needed
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