DLBCL is the most common non-Hodgkin lymphoma among adults. Occurs primarily in older individuals, median age of diagnosis is 70. Can arise in any part of body and is often very aggressive. First sign is rapidly growing mass or tissue infiltration
EPO is a glycoprotein hormone secreted by kidneys in response to cellular hypoxia. Normal blood levels are around 10 mU/mL, while elevated levels can reach 10,000 mU/mL. Produced mainly by kidney interstitial fibroblasts and liver perisinusoidal cells. Highly glycosylated with half-life of around 5 hours in blood
Agglutinin causes particles to coagulate and aggregate in blood. Can be antibodies or sugar-binding protein lectins. Particles aggregate when agglutinin binds to specific structures
Blood smear is a thin blood layer spread on microscope slide. Blood is fixed in methanol before staining with Romanowsky stains. Staining allows examination of white, red blood cells and platelets. Microscope magnification up to 1000 times used for cell examination
Bone marrow is semi-solid tissue found in spongy bone portions. Produces approximately 500 billion blood cells daily. Comprises hematopoietic cells, marrow adipose tissue, and supportive stromal cells. Makes up 5% of total body mass in healthy adults
Kell antigen system determines blood type and targets for autoimmune diseases. System includes K, k, Kpa, Kpb, Jsa and Jsb antigens. Kell protein is a 93-kilodalton zinc-dependent endopeptidase. KEL gene encodes type II transmembrane glycoprotein