Kidney involvement is common in systemic lupus erythematosus (SLE). Up to half of SLE patients develop clinically evident kidney disease. Black, Hispanic, and Asian patients have higher incidence than White patients. Male sex, younger age, and non-White ethnicity increase risk
Journal covers Internal medicine, Nephrology, Surgery, Urology and Endocrinology. Internal medicine research integrates with Gastroenterology and Pathology. Nephrology research includes Urinary system, Dialysis and Radiology. Most cited papers focus on Nephrology with 277 citations
Slow stenosis leads to secondary hypertension through renin hypersecretion. Collateral vessels form and kidney senses reduced flow as low pressure. Angiotensin II causes vasoconstriction and sodium/water retention
Early diagnosis and treatment are crucial for slowing CKD progression. Early referral to nephrologist is essential. Dialysis should be delayed until eGFR drops to 6 mL/min/1.73 m²
Glomerulus is a tuft of capillaries located at beginning of nephron. Each kidney contains about one million nephrons. Glomerular capillaries receive blood from afferent arteriole. Blood exits glomerulus through efferent arteriole instead of venule
Rare inherited disease affecting thick ascending limb of Henle loop. Neonatal type appears between 24-30 weeks with polyhydramnios. Classic type diagnosed later in life, shows polyuria, polydipsia, and growth retardation. Both types cause hypokalemia, metabolic alkalosis, and normal to low blood pressure