Both are corticosteroids that suppress immune system response. Hydrocortisone is available over-the-counter, cortisone requires prescription. Hydrocortisone mimics natural cortisol, cortisone must be processed by liver
Cortisone is a steroid medication used to reduce inflammation in various conditions. It is prescribed for conditions like allergies, skin conditions, and arthritis
Cortisone is a 21-carbon pregnene steroid hormone. It is a naturally occurring corticosteroid metabolite. Must be converted to active cortisol by liver enzyme. Activity is 80-90% lower than direct cortisol administration