NRBCs are red blood cells containing a nucleus. Found in bone marrow of all ages and fetal/newborn blood. Nucleus is ejected during early cell development
MDS is a blood cell disorder where bone marrow cells fail to mature properly. Early symptoms may be absent, later symptoms include fatigue and infections. About 7 per 100,000 people affected, with typical age of onset at 70
EMH occurs outside bone marrow medulla during embryonic and fetal development. Primitive hematopoiesis occurs in yolk sac during early embryonic development. Definitive hematopoiesis produces hematopoietic stem cells in AGM region. Fetal hematopoiesis primarily occurs in liver and spleen
Bone marrow is semi-solid tissue found in spongy bone portions. Produces approximately 500 billion blood cells daily. Comprises hematopoietic cells, marrow adipose tissue, and supportive stromal cells. Makes up 5% of total body mass in healthy adults
Leukemia is a blood cancer affecting bone marrow cells. Approximately 472,714 Americans have leukemia. Five-year survival rate for adults is over 66%
Early form of multiple myeloma without symptoms. Causes high plasma cells in bone marrow and M protein levels. Similar to MGUS but carries higher 5-year risk. Often slowly gets worse without noticeable symptoms