ITP is an autoimmune disorder characterized by low platelet count without other causes. Children have acute form, adults have chronic form. Approximately 60% of cases show platelet antibody detection
TTP causes blood clots in small blood vessels throughout body. Symptoms include bruising, fever, weakness, confusion, and headache. About 1 per 100,000 people affected, typically in adulthood. About 10% of cases begin in childhood
LPDs are conditions characterized by excessive lymphocyte production. Main types include B-cell and T-cell lymphomas, multiple myeloma, and Waldenström's macroglobulinemia. Disorders primarily affect patients with compromised immune systems
Most common enzyme deficiency anemia worldwide affecting 400 million people. X-linked recessive disorder causing premature red blood cell breakdown. Most affected individuals are asymptomatic
Pancytopenia is low levels of all blood cell types in bone marrow. Includes anemia (low RBCs), leukopenia (low WBCs), and thrombocytopenia (low platelets). All blood cells originate from hematopoietic stem cells
JAK2 gene controls blood cell production from hematopoietic stem cells. JAK2 V617F mutation occurs randomly, not inherited. Mutation affects 0.2% of general population, 96% in polycythemia vera