Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. Stabilizes voltage-gated L-type calcium channels in inactive conformation. Inhibits calcium influx in smooth muscle cells, preventing vasoconstriction. Most potent CCB in use with fluorescent activity
Used to treat high blood pressure when valsartan alone is insufficient. Combines valsartan (angiotensin receptor blocker) with hydrochlorothiazide (diuretic). Approved in US in 1998, available as generic medication. Most commonly prescribed medication in US (224th in 2021)
Beta blockers lower blood pressure by blocking epinephrine effects. They slow heartbeat and widen blood vessels. Not recommended as first treatment for high blood pressure alone
Used to lower high blood pressure and reduce stroke risk. Blocks angiotensin II receptors to relax blood vessels. Helps kidneys function better in type 2 diabetes
Indapamide is an oral antihypertensive/diuretic containing both sulfamoyl chlorobenzamide and methylindoline. Available in 1.25 mg and 2.5 mg tablets for oral administration. Starting dose for hypertension is 1.25 mg daily, increasing to 5 mg if needed
Treats symptoms of benign prostatic hyperplasia (BPH). Reduces blood pressure in hypertension patients. Blocks alpha1 adrenergic receptors in prostate and bladder neck