SOFA score was developed in 1994 to assess acute morbidity in critical illness. Score evaluates six organ systems: respiratory, cardiovascular, hepatic, coagulation, renal, neurological. Each system receives a score of 0-4, with increasing scores indicating worsening dysfunction
Sepsis is a leading cause of death worldwide, with 48.9 million cases in 2020. Almost half of cases occur in children under 5 years. For every 1000 hospitalized patients, 15 develop sepsis. Hospital-wide cost exceeds US$32,000 per patient in high-income countries
RSV causes respiratory disease in young children, especially in winter epidemics. RSV-specific IV immunoglobulin prophylaxis recommended for high-risk children
DIC causes widespread blood clots blocking small blood vessels. Symptoms include chest pain, shortness of breath, and bleeding. About 1% of hospital admissions affected, with sepsis rates 20-50%
SIRS is an exaggerated body response to noxious stressors. SIRS with suspected infection is called sepsis. Severe sepsis includes end-organ failures, septic shock is hemodynamic instability. MODS represents altered organ function in acutely ill septic patients
NEWS uses six physiological parameters to assess patient condition. Scores reflect extreme deviations from normal values. Oxygen requirement increases score by 2 points. System uses routine measurements recorded on standardised NEWS2 chart