Rare autoimmune disease characterized by rheumatoid arthritis, splenomegaly, and low neutrophil count. More common in females aged 50-70, Caucasians, and those with chronic rheumatoid arthritis
Synovial joints unite bones with fibrous capsule surrounding synovial cavity. Joint capsule consists of outer fibrous and inner synovial membrane layers. Joint cavity filled with synovial fluid for lubrication and shock absorption. Articular cartilage covers bone ends for smooth movement
Chronic autoimmune disease affecting synovial tissues and joints. Prevalence is 0.5-1%, 2-3 times more common in women. Onset typically occurs in adulthood, peaking in 4th-5th decades
Fatal infusion reactions can occur within 24 hours, with 80% occurring with first infusion. Tumor lysis syndrome can cause acute renal failure requiring dialysis. Severe mucocutaneous reactions, including fatal outcomes, may occur. Progressive multifocal leukoencephalopathy (PML) can result in death. Hepatitis B virus reactivation with fulminant hepatitis possible
Rheumatoid arthritis is an autoimmune disorder that attacks body tissues. Immune system mistakenly attacks synovium lining of joints. Genetic component appears likely but doesn't cause disease itself
Enbrel contains etanercept, an anti-inflammatory medicine. Available as injection solution in powder and prefilled syringes. Approved for use in adults aged 18 and over