Burkitt lymphoma is a highly aggressive B-cell lymphoma. Named after Denis Parsons Burkitt, who first described it in 1958. Overall cure rate in developed countries is about 90%. More common in males than females (3-4:1 ratio)
NHL is a group of blood cancers excluding Hodgkin lymphoma. Main symptoms include enlarged lymph nodes, fever, night sweats, and weight loss. Some forms grow slowly, others rapidly. Unlike Hodgkin lymphoma, NHL is systemic rather than contiguous
DLBCL is the most common non-Hodgkin lymphoma among adults. Occurs primarily in older individuals, median age of diagnosis is 70. Can arise in any part of body and is often very aggressive. First sign is rapidly growing mass or tissue infiltration
Richter's transformation is the conversion of CLL/SLL into DLBCL or HL. About 1-10% of CLL/SLLs develop RT at 0.5-1% per year. Median survival times range from 1.1 to 16.3 months
Primary myelofibrosis is a rare bone marrow blood cancer. Associated with mutations in JAK2, CALR, or MPL genes. Approximately 90% of cases have these gene mutations. JAK2 V617F mutation found in half of patients
B-cell lymphomas are blood cancers affecting lymph nodes. More common in older adults and immunocompromised individuals. Divided into low (indolent) and high (aggressive) grade