B cells produce antibodies that specifically bind antigens during immune response. Goldberg first described this reaction in 1952. Antigens and antibodies combine through agglutination process. Each antibody binds only to specific antigens
Lymph nodes are kidney-shaped organs in lymphatic system. Each node contains outer cortex and inner medulla. Surrounded by fibrous capsule with trabeculae extending inside. About 450 lymph nodes present in adult body
Lymphatic system is part of immune system, complementing circulatory system. System consists of vessels, nodes, organs, tissue and lymph. Lymph is clear fluid carried back to heart for re-circulation. System is open, unlike closed circulatory system
ITP is an autoimmune disorder characterized by low platelet count without other causes. Children have acute form, adults have chronic form. Approximately 60% of cases show platelet antibody detection
Lymphocytes are white blood cells making up 18-42% of circulating WBCs. Main types are T cells (cell-mediated immunity) and B cells (humoral immunity). Natural killer cells (NK cells) play role in innate immunity. Lymphocytes have large nuclei and can be classified as small or large
Immunosuppressants block immune system parts to treat autoimmune diseases and organ transplants. Treatments include traditional drugs like corticosteroids and biologics like Humira. Used for conditions like psoriasis, Crohn's, multiple sclerosis, and organ transplants. Common in cancer treatment as side effect of chemotherapy and radiation