H1 receptor is a G-protein-coupled receptor activated by histamine. Expressed in smooth muscles, endothelial cells, heart, and CNS. Linked to intracellular G-protein activating phospholipase C and IP3 pathways. Crystal structure determined for ligand discovery
Serratiopeptidase is a proteolytic enzyme produced by Serratia sp. E-15 bacteria. Originally isolated from silkworm intestine in late 1960s. Part of Peptidase M10B (Matrixin) family
COX-2 is a sequence homodimer enzyme encoded by PTGS2 gene. Converts arachidonic acid to prostaglandin H2 and prostaglandin endoperoxide H2. Each monomer contains peroxidase and PTGS active sites. Functions as conformational heterodimer with catalytic and allosteric monomers
Common in elderly with emerging itching accompanied by temperature changes. Most common cause is xerosis due to skin barrier degradation. Can be caused by allergies, drugs, diseases, or neurological disorders
Vasodilation is the widening of blood vessels through smooth muscle relaxation. Blood vessel walls consist of endothelial tissue, smooth muscle layers, and adventitia. Sympathetic nervous system maintains semi-constricted vessel state
Itching testicles is a common symptom of various skin conditions. Scratching causes skin tears that can lead to infections. Chafing occurs when scrotum rubs against other skin. Fungal infections thrive in warm, moist areas. Jock itch is a fungal infection causing burning and itching