81 NSCLC patients underwent surgical resection with PET/CT evaluation. SUVmax was measured for primary tumors and lymph node stations. 100 PET/CT positive lymph node stations were analyzed
Tar is toxic resinous matter from tobacco burning. Tar damages lungs through biochemical and mechanical processes. Tar contains mutagenic and carcinogenic agents like polycyclic aromatic hydrocarbons. Tar coats cilia, causing them to die and prevent gas exchange. According to WHO, 80% of lung cancer cases are caused by smoking
Lung cancer is the leading cause of cancer mortality worldwide. Tobacco smoking is the main risk factor, implicated in 90% of cases. Up to 50% of patients are asymptomatic
NSCLC is any epithelial lung cancer except small cell lung cancer. Most common types are squamous cell, large cell, and adenocarcinoma. Smoking is the single most important risk factor. 5-year survival rate from 2013 to 2019 was 25%
Stage 4 lung cancer has spread to distant organs. TNM classification divides stage 4 into 4a (chest spread) and 4b (distant metastasis). Five-year survival rate is 9% according to American Cancer Society
Imfinzi showed 17 months survival in locally advanced NSCLC patients. Combination with tremelimumab improved metastatic NSCLC survival to 14 months. Small cell lung cancer patients lived 13 months with Imfinzi plus chemotherapy. Biliary tract cancer patients lived 12.8 months with Imfinzi plus chemotherapy. Hepatocellular cancer patients lived 16.4 months with Imfinzi plus tremelimumab