2005 yapımı "Fantastik Dörtlü" (Fantastic Four) filminde yer alan bazı oyuncular: Ioan Gruffudd: Reed Richards / Mr. Fantastic; Jessica Alba: Sue Storm / The Invisible Woman; Chris Evans: Johnny Storm / The Human Torch; Michael Chiklis: Ben Grimm / The Thing; Julian McMahon: Dr. Doom; Kerry Washington: Alicia Masters; Hamish Linklater: Leonard; Laurie Holden: Ann Foley; Kevin McNulty: Baxter Building Doorman. Ayrıca, filmde Doug Jones The Silver Surfer karakterini canlandırmıştır.