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    Oncocytoma: Benign Renal Tumor

    pathologyoutlines.com/topic/kidneytumoroncocytoma.html

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    General Characteristics
    • Benign renal epithelial neoplasm with large round eosinophilic cells
    • Accounts for 5-9% of renal tumors, with 2:1 male-female ratio
    • Affects patients aged 24-91, with mean age in 60s
    • Usually asymptomatic, discovered incidentally on imaging
    Pathology
    • Well-circumscribed mass with central stellate scar
    • Contains large round eosinophilic cells with dense granular cytoplasm
    • May show perinephric fat or vascular invasion
    • Can have hybrid morphology with chromophobe renal cell carcinoma
    Molecular Features
    • Often carries mitochondrial mutations
    • May show CCDN1 rearrangements or chromosome Y/1 loss
    • Some cases have p53 mutations, potentially leading to chromophobe carcinoma
    • Associated with Birt-Hogg-Dubé syndrome through FLCN gene mutations
    Diagnosis and Treatment
    • Made through combination of morphology and immunohistochemistry
    • No specific radiologic findings, but central stellate scar suggests diagnosis
    • Treatment options include surveillance or surgical excision
    • Benign tumor with potential for progression to chromophobe carcinoma

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