COX, inflamatuar yanıttan sorumlu prostaglandinleri oluşturan bir enzimdir
COX-1 çoğu dokuda bulunur ve mide-bağırsakları korur
COX-2 öncelikle iltihaplanma bölgelerinde bulunur
Geleneksel NSAID'ler
Motrin, aspirin ve Aleve gibi NSAID'ler prostaglandinleri inhibe eder
Hem COX-1 hem COX-2'yi inhibe ederek gastrointestinal sorunlara neden olabilir
Mide ülseri ve kanama riski nedeniyle bazı hastalıklarda önerilmez
COX-2 İnhibitörleri
1990'ların sonunda sadece COX-2'yi hedefleyen ilaçlar geliştirildi
Celebrex ABD'de kalan tek COX-2 inhibitörüdür
Vioxx ve Bextra kalp krizi riski nedeniyle piyasadan çekildi
COX-2 inhibitörleri daha az gastrointestinal yan etkiye sahiptir
FDA Uyarıları
NSAID kullanımı kalp krizi ve felç riskini artırır
Risk ilk haftalarda başlayabilir ve dozla artabilir
Kalp hastalığı olanlarda risk daha yüksektir
Kalp yetmezliği riskini artırır
Yanıtı değerlendir
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