Gaziantep ile Diyarbakır arası mesafe yaklaşık 308 kilometredir. Ancak bu mesafe, tercih edilen güzergaha ve yol durumuna bağlı olarak küçük farklılıklar gösterebilir. Ulaşım yöntemine göre mesafe şu şekilde değişir: Karayolu: Otobüs veya özel araçla. Havayolu: Uçakla.
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