Slay the Spire oyununda en güçlü karakter Watcher olarak kabul edilir 13.
Bunun nedeni, Watcher'ın yüksek hasar potansiyeli ve değişken duruş mekaniği sayesinde düşmanları hızla yenebilmesidir 14. Ayrıca, Watcher ekstra enerji kazanma ve kartları daha iyi kullanma yeteneğine sahiptir 4.
Slay the Spire oyununa başlarken Ironclad karakteri önerilir. Ironclad, oyunun başlangıç karakteri olup, yüksek savunma yetenekleri ve en yüksek başlangıç HP'si (80) ile öne çıkar.
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