Evet, Grey's Anatomy'nin 10. ve 11. sezonları bağlantılıdır, çünkü 11. sezonun hikayesi, 10. sezonun finalinde yaşanan olayların ardından devam eder. 10. sezonun finalinde, Cristina Yang'in ayrılmasının ardından, 11. sezonun ana hikayelerinden biri, Meredith Grey'in Derek Shepherd ile olan sorunlu aşk hayatı ve yeni yarı kardeşi Maggie Pierce ile ilgili gelişmelerdir.
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